While the best slot machines will vary within each casino, some hotel-casinos in Las Vegas are known for being slightly more loose than others. Rarely do Las Vegas casinos advertise their slots odds, which is why this list includes the best casinos in Las Vegas for slot machines (as voted on by users). Even the best slot machines in Vegas still give the house a significant edge but some offer a better return than others. The best slots in Vegas can be found at many of the top hotels and casinos in Las Vegas, Nevada.